精准医疗与诊断技术分会场

嘉宾简介

姓名        :

朴海龙

报告题目 :

α-catenin, a tumor suppressor in cancer progression

职称        :

研究员

职务        :

PI

工作单位 :

中国科学院大连化学物理研究所

通讯地址 :

大连沙河口区中山路 457号 生物楼 114

教育经历 :

2/25/2009 Division of Applied Biological Science, Gyeongsang National University, Jinju, South Korea, Ph.D., Molecular Biology

2/26/2003 Division of Applied Biological Science, Gyeongsang National University, Jinju, South Korea, M.S., Molecular Biology

工作经历 :

9/2009 –1/2014, Postdoctoral, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

02/2014-05/2015 Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

06/2015-present Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

代表性研究工作 :

1. Chen-Song Zhang, Simon A. Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu, Yu-Qing Wu, Terytty Yang Li, Zhiyun Ye, Shu-Yong Lin, Huiyong Yin, Hai-Long Piao, D. Grahame Hardie, and Sheng-Cai Lin. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature2017 Aug 3;548(7665):112-116.

2. Min Yan, Huan Qi, Shancheng Ren , Jia Li, Guozhu Ye, Yaping Shao, Yinghao Sun, Hai-long Piao#, Guowang Xu#.Identification of metabolic pathways related to SPOP mutations in prostate cancer. Oncotarget, (September 2017, minor revision) (# Co-corresponding authors).

3. Piao HL, Yuan Y, Wang M, Sun Y, Liang H, Ma L. α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling. Nat Cell Biol. 2014 Mar;16(3):245-54.

4. Lin A#, Piao HL#, Zhuang L, Sarbassov dos D, Ma L, Gan B. FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K-AKT Pathway. Cancer Res. 2014 Mar 15;74(6):1682-93. (#Contributed equally to this work)

5. Li Wang, Peijing Zhang, Molkentine DP, Chen C, Molkentine JM, Hai-long Piao, Uma Raju, Jinsong Zhang et al, TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Oncogene. 2016 Jul 18. doi: 10.1038

6. Jia Li, Shancheng Ren, Hai-long Piao, Fubo Wang, Peiyuan Yin, Chuanliang Xu, Xin Lu, Guozhu Ye, Yaping Shao, Min Yan, Xinjie Zhao, Yinghao Sun# & Guowang Xu# . Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryloleate as potential biomarker of prostate cancer. Scientific Reports, 2016 Feb 11;6:20984.

7. Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec;15(12):1486-94.

8. Piao HL, Ma L. Non-coding RNAs as regulators of mammary development and breast cancer. J Mammary Gland Biol Neoplasia. 2012 Mar; 17(1):33-42.